1-Boc-piperazine-3-carboxylic acid, 4-(tert-Butoxycarbonyl)piperazine-2-carboxylic acid, Piperazine-1,3-dicarboxylic acid 1-tert-butyl ester - Names and Identifiers
Name | N-4-Boc-2-piperazinecarboxylic acid
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Synonyms | 4-BOC- (4-N-BOC)PIPERAZINE(2R) COOH 4-BOCpiperazin-2-carboxylic acid 4-Boc-2-piperazinecarboxylic acid 4-BOC-PIPERAZINE-2-CARBOXYLIC ACID 4-N-Boc-2-piperazinecarboxylic acid N-4-Boc-2-piperazinecarboxylic acid 4-N-BOC-PIPERAZINE-2-CARBOXYLIC ACID 4-BOC-PIPERAZINE-2-(R)-CARBOXYLIC ACID (R)-4-Boc-piperazine-2-carboxylid acid 4-(TERT-BUTOXYCARBONYL)PIPERAZINE-2-CARBOXYLIC ACID 4-(TERT-BUTOXYLCARBONYL)-PIPERAZINE-2-CARBOXYLIC ACID 4-(2,2-dimethylpropanoyloxy)piperazine-2-carboxylic acid 1,3-PIPERAZINEDICARBOXYLIC ACID, 1-(1,1-DIMETHYLETHYL) ESTER 1-Boc-piperazine-3-carboxylic acid, 4-(tert-Butoxycarbonyl)piperazine-2-carboxylic acid, Piperazine-1,3-dicarboxylic acid 1-tert-butyl ester 4-Boc-piperazine-2-carboxylic acid,1-Boc-piperazine-3-carboxylic acid, 4-(tert-Butoxycarbonyl)piperazine-2-carboxylic acid, Piperazine-1,3-dicarboxylic acid 1-tert-butyl ester
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CAS | 128019-59-0
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InChI | InChI=1/C10H18N2O4/c1-10(2,3)9(15)16-12-5-4-11-7(6-12)8(13)14/h7,11H,4-6H2,1-3H3,(H,13,14) |
1-Boc-piperazine-3-carboxylic acid, 4-(tert-Butoxycarbonyl)piperazine-2-carboxylic acid, Piperazine-1,3-dicarboxylic acid 1-tert-butyl ester - Physico-chemical Properties
Molecular Formula | C10H18N2O4
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Molar Mass | 230.26 |
Density | 1.193±0.06 g/cm3(Predicted) |
Melting Point | 231-239 °C |
Boling Point | 371.8±37.0 °C(Predicted) |
Flash Point | 174.2°C |
Water Solubility | Slightly soluble in water. |
Vapor Presure | 2.65E-06mmHg at 25°C |
Appearance | powder or crystals |
pKa | 2.20±0.20(Predicted) |
Storage Condition | 2-8°C(protect from light) |
Refractive Index | 1.519 |
MDL | MFCD01076218 |
1-Boc-piperazine-3-carboxylic acid, 4-(tert-Butoxycarbonyl)piperazine-2-carboxylic acid, Piperazine-1,3-dicarboxylic acid 1-tert-butyl ester - Risk and Safety
Hazard Symbols | Xi - Irritant
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Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin.
R43 - May cause sensitization by skin contact
R36 - Irritating to the eyes
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Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
S36/37 - Wear suitable protective clothing and gloves.
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WGK Germany | 3 |
HS Code | 29335990 |
Hazard Class | IRRITANT |
1-Boc-piperazine-3-carboxylic acid, 4-(tert-Butoxycarbonyl)piperazine-2-carboxylic acid, Piperazine-1,3-dicarboxylic acid 1-tert-butyl ester - Introduction
4-Boc-piperazine-2-carboxylic acid, full name acid, is an organic compound. The following is a description of its nature, use, preparation and safety information:
Nature:
4-Boc-piperazine-2-carboxylic acid is a colorless crystal or white solid with good solubility. It is a carboxylic acid compound containing a very stable 4-tert-butoxycarbonyl protecting group. Its chemical structure contains piperazine and pyrimidine rings, and there is a carboxyl group on the pyrimidine ring.
Use:
4-Boc-piperazine-2-carboxylic acid is a commonly used organic synthesis intermediate, which can be used to synthesize various organic compounds. It is often used in the field of drug synthesis as a key raw material for the synthesis of certain drug molecules. In addition, it can also be used in dye synthesis, ligand synthesis and enzymatic research.
Preparation Method:
The preparation method of 4-Boc-piperazine-2-carboxylic acid usually involves the modification of piperazine compounds. A common synthesis method is to react piperazine with the corresponding acid chloride, then use tetra-tert-butyl perpotassium carbonate (TBHP) and osmium tetroxide (OsO4) system for oxidation, and finally through hydrolysis reaction to obtain the target product.
Safety Information:
Last Update:2024-04-09 20:52:54